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Carbonyldiimidazole (CDI) is an organic compound with the molecular formula (C3H3N2)2CO. It is a white crystalline solid. It is often used for the coupling of amino acids for peptide synthesis and as a reagent in organic synthesis. The formation of amide is promoted by CDI. Although the reactivity of CDI is less than acid chlorides, it is more easily handled and avoids the

use of thionyl chloride in acid chloride formation, which can cause side reactions.